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NUTRITIONAL SUPPLEMENT STATINIX IS INTENDED FOR NUTRITION SUPPORT WHILE TAKING STATINS.

Recommended daily dose: 1 capsule per day during a meal. Recommended during regular use of statins. 30 capsules are sufficient for 1 month therapy. The capsules contain a special, enteric wrap (microcrystalline cellulose), which allows safe passage of the active ingredients through the stomach. Suitable for vegetarians. The product does not contain lactose, salt, gluten, artificial colors, flavors or preservatives.

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Zinc
0mg
100%*
Coenzyme Q10
0mg
Coconut Oil
0mg
Vitamin E
0mg
100%*
Vitamin K2
0μg
100%*
* Daily dose content by recommended daily amount

Pharmaceuticals are mostly made from chemical substances which can cause unwanted side effects and contribute to the deficit of nutrients. When the body tries to detoxify any side products of the drug, the lack of nutrients may result from inhibition of nutrient absorption, large differences in the biochemical system, or the weakening of the organs.

Today, more than 30% of people in North America and Europe aged over 45 years are taking statins (1), medicines to lower cholesterol in the blood. Statins are one of the most commonly prescribed drug groups that successfully lower cholesterol levels (inhibit the formation of cholesterol in the liver), thereby preventing the onset of stroke and heart attack. Statins also reduce the formation of very low-density lipoproteins (VLDL), which are the major carrier of triglycerides in the blood, and have other protective properties for vascular walls that are not directly related to the regulation of the level of fat in the blood.

The fact is that with the regular administration of statins, the biosynthesis of coenzyme Q10 is inhibited and the absorption of zinc and vitamin K2 is disturbed, which will be presented below. While statins help keep cholesterol levels under control, they can also exhaust your body of the essential compounds and nutrients that keep your body healthy and active.


 
  • Coenzyme Q10

    From our vital organs to muscles, everywhere, in each cell, we find Coenzyme Q10. CoQ10 regulates electrons, participates in the production of energy and combats free radicals. According to the American cardiologist Peter Langsjoen, who is aware of the relationship between statin treatment and reduced CoQ10 content in the body for multiple years now, the exhaustion of coenzyme Q10 while taking statins is something we have to pay special attention to. Scientific evidence, also provided by the Food and Drug Administration (FDA) and EFSA (European Food Safety Authority), “show a significant reduction in coenzyme Q10 in patients treated with a statin” states dr. Langsjoen. New research clearly shows the value and regularity of the study published in the Journal of Clinical Pharmacology, which showed that after three months of statin treatment (mean dose of 20 mg), blood CoQ10 decreased up to 40%. Treatment with higher doses reduces CoQ10 levels by more than 70%! More scientific research has shown that by adding dietary supplements with CoQ10, we can reduce unwanted effects of statins. For example, US researchers published a study in the US in 2007 inthe Journal of Cardiology (2), describing how a 30-day supplementation with CoQ10 led to a 40 percent reduction in painsin muscles in patients treated with a statin. In other words, patients can better tolerate statin therapy without having the side effectsreduce their daily activities. An important finding according to dr. Peter H. Langsjoen is “consequenceof the reduction in CoQ10 levels in the use of statins results from a partially biosynthetic pathway of CoQ10 and cholesterol. Negative effects of the CoQ10 shortage must be countered with a regular addition of a CoQ10 oral supplement. “According to clinical research of the University of Maryland Medical Centre (UMMC), there is no doubt that statins will “reduce the natural levels of CoQ10 in the body”. In fact, statins have been shown to reduce CoQ10 levels by as much as 40%. This can potentially cause other health problems and emphasizes side effects of taking statins. But there are some good news. UMMC reportsthat “taking CoQ10 supplements can help improve levels in the body and reduce problems”. Furthermore, research suggests that CoQ10 can support a healthy cardiovascular function – something worth considering especially if you have a history of heart disease in your family.

  • What happens when there is a lack of CoQ10?

    When we become older CoQ10 levels naturally decline, and researchers have found that CoQ10 deficiency contributes to many unwanted health conditions. Cardiovascular problems are probably the most common indication of the effect of CoQ10 deficiency, which includes heart failure, angina pectoris, high blood pressure, high cholesterol, and various cardiovascular diseases.

  • Q10 and pain in muscles due to taking statins

    Our muscle fibers are constantly broken down and restored to become stronger. Old muscle cells die off and give space to fresh cells that are filled with life. Deep within these muscle fibers you will find CoQ10, which provides the necessary fresh energy to cells and, with its antioxidant action, prevents intrusions. But when the normal levels of CoQ10 are endangered by the statins, defects occur in the correct muscle function and the entire process begins to collapse. The result is muscle pain and stiffness of the joints – one of the common adverse effects of statins. Muscle pain can seriously affect our mobility, not to mention the quality of life. According to a study published in the American Journal of Cardiology (2), CoQ10 helps relieve muscle pain and discomfort in joints caused by statins: “The results suggest that the supplementation of coenzyme Q10 can reduce muscle pain associated with statin therapy. Thus, the addition of coenzyme Q10 offers excellent support in the treatment with these vital medicines “American Journal of Cardiology; effect of coenzyme Q10 on myopathic symptoms in statin-treated patients (2). So we see that CoQ10 is essential for maintaining the health of the heart and other organs and is also important for the proper functioning of the muscles (3, 4, 5, 6, 7, 8).

  • Vitamin K2

    The study, which was very shocking to all cardiologists and statin users, was published in 2015 in the Expert Review of Clinical Pharmacology. The study says that, contrary to popular belief, it is most likely that statins can also promote the development of atherosclerosis. Statins reduce the ability to synthesize vitamin K2 in the body, which results in arterial calcification. Vitamin K2 carries calcium to those places in the body where it is needed (bones, teeth). As noted in Expert Review of Clinical Pharmacology (9), contrary to the current belief that cholesterol reduction in statins reduces atherosclerosis, these drugs can actually promote atherosclerosis and heart failure. The study explained several physiological mechanisms that demonstrate how the statin medicinal product can impair cardiac function due to inhibition of absorption of vitamin K2. Vitamin K2 protects your arteries from calcification. The most important biological role of vitamin K2 is that it helps to move calcium to the relevant areas of your body, such as bones and teeth. It also plays a role in the removal of calcium from areas where it should not be, for example in our arteries and soft tissues. According to the Netherlands study of 2009 (10), vitamin K2 is associated with reduced vascular calcification even in small dietary intakes. Statins inhibit the activity of vitamin K2 in our body, which means that we are therefore more susceptible to diseases caused by vitamin K2 deficiency, such as: osteoporosis, heart disease, cardiac failure and inadequate calcification. If the majority of statin users today are aware that they need to add CoQ10 to the statin, because the drug exhausts this nutrient, most are not (yet) aware of the need to add vitamin K2 in order to avoid cardiovascular risks associated with statins.

  • Zinc

    Zinc deficiency is nowadays widespread. Deficiency rates increase with age, due to poor absorption of micro-nutrients in older adults and food with a high amount of processed grains containing phytates. Zinc deficiency can often be observed under conditions such as diabetes, increased cholesterol, liver and kidney disease, macular degeneration and melanomas. Zinc deficiency can be harmful because zinc is required for the proper functioning of more than 300 enzymes. It detoxifies alcohol, helps protein digestion, regulates gene expression, helps regulate insulin receptors, and facilitates thyroid hormones. It also protects our DNA against damage and improves our immune system. Many medicines you may be taking can inhibit the absorption of zinc. These may include oral contraceptives, ACE inhibitors, diuretics, anti-ulcer and cholesterol-lowering agents. A newer quality study carried out in 2015 (11) proves that zinc supplementation has beneficial effects on plasma lipid parameters. Zinc supplementation significantly reduced total cholesterol, LDL cholesterol and triglycerides. In addition, the supplementation of zinc in unhealthy patients showed a significant increase in the good HDL cholesterol. Therefore, at the end of the study, it is concluded that it is sensible to supplement zinc in the treatment of elevated cholesterol in the blood with statins. Also, the study of 2009 (12) identifies similar effects when adding zinc with markedly positive effects upon check-ups after 42 days. As there is more evidence that statins lower the level of zinc absorption in our body, it is essential to supplement zinc when taking statins. Zinc also has positive effects on cholesterol and thus helps in the functioning of statins. Zinc deficiency will be primarily observed in the form of a weakened immune system, changes, and a worse sense of smell and taste, the appearance of rash and hair loss.

  • Vitamin E

    Vitamin E is one of the most important natural antioxidants, and its plasma concentrations are parallel to the progression of atherosclerosis. Several reports and studies testify to the possible negative effect of treatment with statins on the levels of vitamin E in the body. A comprehensive study of the effect of vitamin E in patients with coronary disease (13) found that at high doses of vitamin E (at least 100% of recommended daily allowance per day), the risk of heart attack was reduced by as much as 77%. The fact is that vitamin E is fat soluble vitamin, which means that it is metabolised by the use of lipids (cholesterol). An artificial decrease in blood cholesterol (using statins) means less naturally occurring vitamin E. It has been shown that the use of a statin reduces the amount of vitamin E by up to 17%. A lack of vitamin E can cause problems with the nervous system, including reflex problems, as well as muscle pain, myalgia, and muscle weakness.

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For you, we have chosen the best research on which the above claims are based.
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Sources:

  1.  Gu Q, Paulose-Ram R, Burt VL, Kit BK. Prescription cholesterol-lowering medication use in adults aged 40 and over: United States, 2003-2012. NCHS Data Brief. 2014 Dec;(177):1-8
  2. Caso G, et al. Effect of coenzyme Q10 on myopathic symptoms in patients treated with statins. Am J Cardiol. 2007;99(19):1409-12
  3. Fedacko J, et al. Coenzyme Q10 and selenium in statin-associated myopathy treatment. Can J Physiol Pharmacol 2013;91:165-70
  4. Larsen S, et al. Simvastatin Effects on Skeletal Muscle. Relation to Decreased Mitochondrial Function and Glucose Intolerance. J Am Coll Cardiol. 2013;61(1):44-53
  5. Zlatohlavek L, et al. The effect of coenzyme Q10 in statin myopathy. Neuro Endocrinol Lett. 2012;33 Suppl 2:98-101
  6. Silver M.A. et al. Effect of atorvastatin on left ventricular diastolic function and ability of coenzyme Q10 to reverse that dysfunction. The American Journal of Cardiology. 2004;94(10), 1306-10
  7. Pourmoghaddas, M., et al. Combination of atorvastatin/coenzyme Q10 as adjunctive treatment in congestive heart failure: A double-blind randomized placebo-controlled clinical trial. ARYA Atherosclerosis. 2014; 10(1), 1-5
  8. Deichmann R, Lavie C, Andrews S. Coenzyme Q10 and Statin-Induced Mitochondrial Dysfunction. The Ochsner Journal. 2010;10(1):16-21
  9. Okuyama H, Langsjoen PH, Hamazaki T, Ogushi Y, Hama R, Kobayashi T, Uchino H. Statins stimulate atherosclerosis and heart failure: pharmacological mechanisms. Expert Rev Clin Pharmacol. 2015 Mar;8(2):189-99
  10. Van Rein, N., Biedermann, J.S., Bonafacio, S.M. et al. Eur J Clin Pharmacol (2016) 72: 1441.
  11. Ranasinghe, P., Wathurapatha, W., Ishara, M., Jayawardana, R., Galappatthy, P., Katulanda, P., & Constantine, G. (2015). Effects of Zinc supplementation on serum lipids: a systematic review and meta-analysis. Nutrition & Metabolism, 12, 26
  12. Ranasinghe P, Wathurapatha W, Ishara M, et al. Effects of Zinc supplementation on serum lipids: a systematic review and meta-analysis. Nutrition & Metabolism. 2015;12:26
  13. N.G. Stephens MRCPA, Parsons RN, P.M. Schofield FRCP, F. Kelly PhD, K. Cheeseman PhD, M.J. Mitchinson FRCPath. Randomised controlled trial of vitamin E in patients with coronary disease: Cambridge Heart Antioxidant Study (CHAOS), The Lancet, Volume 347, Issue 9004, 23 March 1996, 781-786

Other literature:

  • Coenzyme Q10; Robert Alan Bonakdar, M.D., Erminia Guarneri, M.D. Scripps Center for Integrative Medicine, La Jolla, California Am Fam Physician. 2005 Sep 15;72(6):1065-1070
  • Awang D. Milk thistle. Can Pharm J1993; 422, 403- 404.
  • Wagner H. Antihepatotoxic flavonoids. Plant Flavonoids in Biology and medicine: Biochemical, Pharmacological, and Structure-Activity Relationships. 1986; Alan R. Liss, New York, pp. 545- 558
  • Adzet T. Polyphenolic compounds with biological and pharmacological activity. Herbs Spices Med Plants1986;1,167-184
  • Sohet, Florence M., Audrey M. Neyrinck, Barbara D. Pachikian, Fabienne C. De Backer, Laure B. Bindels, Petra Niklowitz, Thomas Menke, Patrice D. Cani, and Nathalie M. Delzenne. “Coenzyme Q10 Supplementation Lowers Hepatic Oxidative Stress and Inflammation Associated with Diet-induced Obesity in Mice.” Biochemical Pharmacology78, no. 11 (2009): 1391-400
  • EPA Therapy Added to Statin Therapy Showed Coronary Plaque Regression at Approximately Twice the Prevalence Compared to Statin Therapy Alone in Japanese Clinical Study http://thestockmarketwatch. com/news/read.aspx/epa-therapy-added-to-statin- therapy-showed-coronary-plaque-regression-at- approximately-twice-the-prevalence-compared- to-statin-therapy-alone-in-japanese-clinical-study/ a6c4f7ee8b2b70da45b3ee83e2c14e59/ -1105