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Nutrition supplement onix is intended as nutritional support for patients with cancer.

Recommended daily dose: 1 capsule per day during a meal. We recommend taking the supplement through oout the treatment as well as after cessation (as prevention). One pack is sufficient for 30 days. Capsules contain spetial enterical wrap (microcrystal celulose), which enables a safe passage of ingredients throug the stomach. Suitable for vegetarians. The product does not contain lactose, salt, gluten, artificial colors, flavors or preservatives.
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Zinc
0mg
100%*
Pantothenic Acid
0mg
300%*
Selenium
0μg
182%*
Vitamin A
0μg
62,5%*
Vitamin B1 (Tiamin)
0mg
500%*
Vitamin B2 (Riboflavin)
0μg
500%*
Vitamin B3 (Niacin)
0mg
300%*
Vitamin B6
0mg
300%*
Vitamin B7 (Biotin)
0μg
500%*
Vitamin B9 (Folic Acid)
0μg
200%*
Vitamin B12
0μg
500%*
Vitamin C
0mg
500%*
Vitamin E
0mg
200%*
Vitamin C
0mg
500%*
 
* Daily dose content by recommended daily amount

Vitamins are essential for health and are needed in various biochemical and physiological processes of the body. Vitamins are divided into soluble in fats(A, D, E and K) and water-soluble (C and vitamin B groups). Due to numerous studies on vitamins and their role in helpingand in the treatment of cancer that was published recent ly, it is essential that all scientific information be collected in single, transparent arti cle that will clearly identify the vitamins and minerals that help with this serious illness. To this end, we at Medilek collected a lot of data from high quality cli nical research on the most promising vitamins and minerals. We then took this information into account when developing the product called Onix.


 
  • Vitamin A

    Vitamin A participates in a wide range of biological activities, such as reproduction, embryogenesis, growth, differentiation, proliferation, apoptosis, vision, bone formation, metabolism, haematopoiesis and in many immune processes. Given the great importance of the mechanisms with which vitamin A and retinoids work at the cellular level, their use in the prevention and treatment of cancer has already triggered numerous studies. Thus, for example, Wolbach and Howe (1), and later also Lasnitzki (2) and Logan (3) proved the important role of vitamin A and retinoids in the oncogenesis of many tissues. Lotan (4) showed with in vitro and in vivo study that these compounds can, in various ways affect the growth of malignant cells, by preparing growth, apoptosis and redifering into different cellslines. We know that the homeostasis of vitamin A and retinoids changes in many types of tumors, including leukemia, breast cancer, skin, mouth, prostate and cervical carcinoma. A poor conversion of retinol to retinoic acid is found in cell lines of breast cancer, and recently, based on Williams et al. (5), the same results are shown in cancerous ovarian cells. These results support the hypothesis that the metabolism of vitamin A contributes to ovarian oncogenesis.

  • B vitamins

    B vitamin complex contains several water-soluble vitamins: B1 (thiamin), B2 (riboflavin), B3 (niacin), B5 (pantothenic acid), B6 (pyridoxine), B7 (biotin), B9 (folic acid) and B12 cobalamin). Group B vitamins maintain and increase metabolic rate, maintain muscle tone, provide a good skin condition, improve the functions of the nervous and immune system and stimulate cell growth and division. A number of epidemiological studies have shown that an appropriate input of group B vitamins is important for the prevention of breast cancer. A high quality study was carried out by Zhang et al. (6), who studied the ratio of folate, vitamin B6 to vitamin B12, and the risk of breast cancer, which also took into account the consumption of alcohol because it changes the normal folate metabolism in many ways. The authors concluded that high levels of folate in plasma and possibly vitamin B6 can reduce the risk of developing this pathology, especially in women with a higher risk of developing breast cancer due to increased alcohol consumption. Low folate is also associated with a higher risk of gastrointestinal cancer, including gastric cancer. Krumdieck (7) also successfully demonstrated the hypothesis of epithelial forms of cancer, such as cervical cancer, lung cancer and bladder cancer, which may be due to folic acid deficiency, vitamin B12 and other vitamins of group B.

  • Vitamin C

    Vitamin C is a water soluble antioxidant, which is present in plants and certain animals. Unlike most mammals, humans do not have the ability to synthesize this nutrient endogenously and must therefore obtain it through nutrition and nutritional supplements. Vitamin C is one of the most well-known natural medicines that is shown by studies to also be effective in the treatment of cancer. Not only does it kill tumor cells – patients who are receiving it are more likely to tolerate chemotherapy and have fewer side effects. Taking into account the important characteristics of vitamin C, several studies have been carried out that show the benefit of supplementing vitamin C in the prevention and treatment of cancer. Unfortunately, clinical practice is still controversial, although studies have shown that the patients with cancer. Their results were very promising in the use of vitamin in the treatment of cancer. Verrax and Calderon (8) have shown that high vitamin C doses have positive anti-cancer effects in studies that have been performed both in vitro and in vivo. Several lines of cancer cells that have been exposed to high doses of vitamin C over 2 hours have been used. The pharmacological concentrations of vitamin C have been found to destroy these high-efficiency tuberculosis cells (EC50 in the range of 3 to 7 mM). Yeom et al. have also carried out a study in vivo (9) to test the carcinostatic effects of vitamin C in mice with sarcoma cells. The survival rate increased by 20% in the group receiving high concentrations of vitamin C versus the control group. These results have shown that high concentrations of vitamin C can inhibit angiogenesis in cancer cells. A study on the efficacy of vitamin C as a cancer product was also performed in 27 patients with advanced ovarian cancer (10). They all were all diagnosed with the disease only when it was already in the stages three or four. All patients were treated with chemotherapy (paclitaxel or carboplatin), while for half the patients, high doses of vitamin C were added to the chemotherapy. Tumors in those receiving vitamin C decreased and the chemotherapy was more easily tolerated by the patients. High doses of vitamin C were not toxic to healthy cells and did not cause undesirable changes in the kidneys, liver and spleen. And how does vitamin C affect cancer cells? “Experiments on tumor models and on cancerous cells in laboratory animals have shown that vitamin C results in the formation of hydrogen peroxide in an intercellular space that damages the DNA of cancer cells and inhibits their growth. We also noticed that vitamin C improved the effect of chemotherapy,” said one of the authors of the research dr. Jeanne Drisko of the University of Kansas.

  • Vitamin D

    Epidemiological studies prove (11) that as much as 40-75% of the population is in vitamin D deficiency, and during the period when the sun’s rays shine on Earth at a sharp angle, from October to April, this estimate should go up to 90% of the healthy population. Many experts therefore believe that we can talk about the epidemic and a pandemic of vitamin D deficiency. Many studies have shown that there is a strong link between vitamin D and the various, as well as most common forms of cancer (cancer of the breast, bowel cancer, prostate cancer, lung cancer, cancer pancreas, cervical cancer, ovarian cancer …) (12). Theories that link vitamin D deficiency to cancer have been tested and confirmed in more than 257 epidemiological studies. One study in 2011 (13) has shown not only that low levels of vitamin D are associated with breast cancer, but that they can also be associated with the risk of developing the most aggressive forms of cancer. Researchers at the University of Rochester Medical Center have tested the level of vitamin D in 155 breast cancer patients in the months before or after surgery to treat cancer. They found that suboptimal levels of vitamin D are associated with the presence of biological markers associated with more aggressive types of tumors. A completely new study published in the American Journal of Clinical Nutrition (14) in October 2015 has shown that vitamin D3 prevents the development of breast cancer, which has its cause in the action of the estrogen hormone. The study was carried out on more than 57,000 postmenopausal women who received replacement hormone therapy and showed that the consumption of vitamin D reduced the risk of breast cancer by 26%.

  • Vitamin E

    In the last two decades, scientists have focused heavily on the role of vitamin E in cancer and have undergone numerous studies. It has been established that vitamin E may be an important protective agent against lung cancer, as shown by Wang X and Quinn PJ (15, 16). These studies have shown that vitamin E reduces cell proliferation in in vitro and in vivo research. In order to determine the relationship between vitamin E and the risk of liver cancer, researchers at the University of Shanghai have tested 132,837 volunteers (17). In this way, they acquired data on an individual’s eating habits, using validated questionnaires on the nutritional frequency. Participants in the study were studied in terms of food quality and vitamin E content in it, and vitamin E supplements. They compared the risk of liver cancer in the high and low-intake group of the vitamin E. The researchers say that a clear link exists between the intake of vitamin E and the risk of hepatic cancer. The higher intake of Vitamin E with nutrition and vitamin supplements was in both cases associated with a lower risk of developing liver cancer, which is one of the most common types of cancer.

  • Zinc

    Microelement selen fulfills many vital tasks. Today, it also has the reputation of potentially powerful weapons against cancer and other diseases. It comes out of soil and if there is too little selenium in it, it is not enough to get it with the food that grows in such soil. In the human body, most selenium is located in the kidneys, liver, spleen, pancreas and testes. Selenium in the body acts as an antioxidant and prevents free radicals that damage the molecules of deoxyribonucleic acid (DNA). Selenium is an integral part of the antioxidant glutathione peroxidase enzyme that protects cells against harmful substances from the environment and food. In April 2013, in the United States, the United States Agency for Research on Cancer (AACR), for the first time, presented a study confirming the link between the content of selenium and cancer (33). It has been found that higher selenium concentrations are associated with a reduction in the risk of developing and progressing prostate cancer, breast cancer, metastases (in all cases it is more than 60% lower risk). 100 μg of selenium daily already reduces the risk of cancer by 50%. In addition to preventing the disease, selenium has been proven to help slow down the progression of cancer in patients who already have it. According to the Life Extension Foundation (34), the use of selenium during chemotherapy in combination with vitamins A and E reduces the toxicity of chemotherapeutic drugs. The mineral also helps “strengthen the effectiveness of chemotherapy, irradiation and hyperthermia, while at the same time minimizing damage to the patient’s normal cells; which makes the therapy more selective, “says Patrick Quillin in the book Beating Cancer with Nutrition. Dr. Larry Clark of the University of Arizona, in a 1996 study, revealed how effective selenium is as protection against cancer (35). The study involved 1312 elderly people, and showed that the incidence of cancer among those taking 200 micrograms of selenium decreased by 42 percent over a period of seven years per day compared to those taking placebo. According to the Journal of the American Medical Association (36), cancer mortality was almost halved for those who took selenium. While the results of the study confirm that selenium protects against all types of cancer, this is particularly true of prostate, supplements as a help in the treatment of cancer for quite a few steps forward. ” Selenium receives great attention precisely because of its potential role in overcoming cancer. Research at Cornell University and Arizona University (37) found that taking 200 micrograms of selenium per day reduced the number of cases of prostate cancer by 63 percent, bowel cancer by 58 percent, lung cancer by 46 percent, and all cancer deaths by 39 percent. Other studies have confirmed that selenium can help prevent ovarian, cervical, rectal, bladder, esophagus, pancreatic, liver and leukemia. Studies in cancer patients show that in those with low concentrations, selenium in the blood has developed several tumors, and the disease was repeated earlier than in those with higher concentrations.

  • Selenium

    Mikroelement selen izpolnjuje številne življenjsko pomembne naloge. Danes ima med drugim tudi sloves morebitnega močnega orožja proti raku in drugim boleznim. Izhaja iz zemlje in če je v njej premalo selena, ga premalo dobimo tudi s hrano, ki v tej zemlji raste. V človeškem telesu je največ selena v ledvicah, jetrih, vranici, trebušni slinavki in modih. Selen v telesu deluje kot antioksidant in preprečuje delovanje prostih radikalov, ki škodujejo molekulam deoksiribonukleinske kisline (DNK). Selen je namreč sestavni del antioksidativnega encima glutation peroksidaze, ki varuje celice pred škodljivimi snovmi iz okolja in prehrane. Aprila 2013 so v ZDA na srečanju Ameriške zveze za raziskave raka (AACR) prvič predstavili raziskavo v kateri so potrdili povezavo med vsebnostjo selena in rakom (33). Ugotovili so, da so višje koncentracije selena povezane z zmanjšanjem tveganja za nastanek in napredovanje raka prostate, raka dojk, metastaz (v vseh primerih gre za več kot 60 % nižja tveganja). Že 100 μg selena dnevno zniža tveganje za raka za 50 %. Poleg preprečevanja nastanka bolezni so za selen dokazali, da pomaga upočasniti napredovanje raka pri pacientih, ki ga že imajo. Po mnenju ustanove Life Extension Foundation (34), uporaba selena med kemoterapijo v kombinaciji z vitaminom A in E zmanjša toksičnost kemoterapevtskih zdravil. Mineral poleg tega pomaga “okrepiti učinkovitost kemoterapije, obsevanja in hipertermije, medtem ko istočasno minimizira škodo na pacientovih normalnih celicah; zaradi česar je terapija bolj selektivna,” trdi Patrick Quillin v knjigi Beating Cancer with Nutrition. Dr. Larry Clark z Univerze Arizona je v raziskavi leta 1996 razkril, kako učinkovit je selen kot zaščita pred rakom (35). V študiji je sodelovalo 1312 starostnikov, pokazala pa je, da se je pojavnost raka med tistimi, ki so jemali 200 mikrogramov selena dnevno v obdobju sedmih let zmanjšala za 42 odstotkov v primerjavi s tistimi, ki so jemali placebo. Po navedbah revije Journal of the American Medical Association (36) se je smrtnost zaradi raka pri tistih, ki so jemali selen skoraj prepolovila. Medtem ko rezultati študije potrjujejo, da selen ščiti pred vsemi vrstami raka, to še posebej drži za raka prostate, črevesja in pljuč. Jean Carper je v knjigi Miracle Cures, označila dr. Clarkovo odkritje kot “nepredstavljivo pomembna raziskava o raku”, ki je “premaknila sprejemanje uporabe prehranskih dopolnil kot pomoč pri zdravljenju raka kar za nekaj korakov naprej”. Selen je deležen velike pozornosti ravno zaradi svoje morebitne vloge pri premagovanju raka. Z raziskavama na univerzi Cornell in na univerzi Arizona (37) so ugotovili, da je jemanje 200 mikrogramov selena na dan zmanjšalo število primerov raka prostate za 63 odstotkov, raka črevesja za 58 odstotkov, pljučnega raka za 46 odstotkov ter vseh smrti zaradi raka za 39 odstotkov. Druge raziskave so potrdile, da selen lahko pomaga preprečevati raka jajčnikov, materničnega vratu, danke, mehurja, požiralnika, trebušne slinavke, jeter in tudi levkemijo. Preučevanja rakavih bolnikov kažejo, da se je pri tistih z nizkimi koncentracijami selena v krvi razvilo več tumorjev in se jim je bolezen prej ponovila kot pri tistih z višjimi koncentracijami.

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For you, we have chosen the best research on which the above claims are based.

View Research

Sources:

  1. Wolbach SB, Howe PR. Tissue changes following deprivation of fat-soluble A vitamin. The Journal of Experimental Medicine. 1925;42(6):753-777
  2. Lasnitzki I. Hypovitaminosis-A in the mouse prostate gland cultured in chemically defined medium. Experimental Cell Research Volume 28, Issue 1, November 1962, Pages 40-51
  3. Logan WS. Vitamin A and Keratinization. Arch Dermatol. 1972;105(5):748–753
  4. Lotan R. Effects of vitamin A and its analogs (retinoids) on normal and neoplastic cells. Biochimica et Biophysica Acta (BBA) - Reviews on Cancer Volume 605, Issue 1, 12 March 1980, Pages 33-91
  5. Williams SJ, Cvetkovic D, Hamilton TC. Vitamin A Metabolism is Impaired in Human Ovarian Cancer. Gynecologic oncology. 2009;112(3):637-645
  6. Zhang SM, Cook NR, Albert CM, Gaziano JM, Buring JE, Manson JE. Effect of Combined Folic Acid, Vitamin B6, and Vitamin B12 on Cancer Risk: Results from a Randomized Trial. JAMA : the journal of the American Medical Association. 2008;300(17):2012-2021
  7. Eto I, Krumdieck CL. Role of vitamin B12 and folate deficiencies in carcinogenesis. Adv Exp Med Biol. 1986;206:313-30
  8. Ewan Cameron, Linus Pauling. The orthomolecular treatment of cancer I. The role of ascorbic acid in host resistance. Chemico-Biological Interactions Volume 9, Issue 4, October 1974, Pages 273-283
  9. Yeom C-H, Lee G, Park J-H, et al. High dose concentration administration of ascorbic acid inhibits tumor growth in BALB/C mice implanted with sarcoma 180 cancer cells via the restriction of angiogenesis. Journal of Translational Medicine. 2009;7:70.
  10. Yan Ma, Julia Chapman, Mark Levine, Kishore Polireddy, Jeanne Drisko, Qi Chen High-Dose Parenteral Ascorbate Enhanced Chemosensitivity of Ovarian Cancer and Reduced Toxicity of Chemotherapy. Science Translational Medicine05 Feb 2014 : 222ra18
  11. http://selfhealthtoday.org/scientists-call-daction-vitamin-d-deficiency-epidemic. Dostopano 20.2.2018
  12. Garland CF, Garland FC, Gorham ED, et al. The Role of Vitamin D in Cancer Prevention. American Journal of Public Health. 2006;96(2):252-261
  13. https://www.urmc.rochester.edu/news/story/3182/aggressive-breast-tumors-linked-to-vitamin-d-deficiency.aspx. Objavljeno 29.4.2011, dostopano 20.2.2018
  14. http://nutrition.nutricionizam.com/vitamin-d-and-breast-cancer. Objavljeno 17.12.2015, dostopano 20.2.2018
  15. Wang X, Quinn PJ. Vitamin E and its function in membranes. Prog Lipid Res. 1999 Jul;38(4):309-36
  16. Wang X, Quinn PJ.The location and function of vitamin E in membranes (review). Mol Membr Biol. 2000 Jul-Sep;17(3):143-56
  17. Zhang W, Shu X-O, Li H, et al. Vitamin Intake and Liver Cancer Risk: A Report From Two Cohort Studies in China. JNCI Journal of the National Cancer Institute. 2012;104(15):1174-1182.
  18. Ananda S. Prasad, MD, James A. Halsted M.D, Manucher Nadimi MD. Syndrome of iron deficiency anemia, hepatosplenomegaly, hypogonadism, dwarfism and geophagia. AJM October 1961 Volume 31, Issue 4, Pages 532–546
  19. Prasad AS. Zinc is an Antioxidant and Anti-Inflammatory Agent: Its Role in Human Health. Frontiers in Nutrition. 2014;1:1
  20. Mittal P and Dipti B. Role of Zinc in Malnutrition. Ann Nutr Disord & Ther. 2016; 3(1): 1029. ISSN : 2381-8891
  21. Prasad AS. Zinc: role in immunity, oxidative stress and chronic inflammation. Curr Opin Clin Nutr Metab Care. 2009 Nov;12(6):646-52
  22. Prasad AS, Beck FW, Snell DC, Kucuk O. Zinc in cancer prevention. Nutr Cancer. 2009;61(6):879-87
  23. Ho E. Zinc deficiency, DNA damage and cancer risk. J Nutr Biochem 2004 Oct;15(10):572-8
  24. Sliwinski, T., Czechowska, A., Kolodziejczak, M., Jajte, J., Wisniewska-Jarosinska, M. and Blasiak, J. (2009), Zinc salts differentially modulate DNA damage in normal and cancer cells. Cell Biology International, 33: 542–547
  25. Dani V, Goel A, Vaiphei K, Dhawan DK. Chemopreventive potential of zinc in experimentally induced colon carcinogenesis. Toxicol Lett. 2007 Jun 15;171(1-2):10-8
  26. Dani V, Vaiphei K, Dhawan DK. Zinc mediated normalization of histoarchitecture and antioxidant status offers protection against initiation of experimental carcinogenesis. Mol Cell Biochem. 2007;27:595–607
  27. Dani V, Dhawan DK. Membrane fluidity and surface changes during initiation of 1,2 dimethylhydrazine induced colon carcinogenesis: Protection by Zinc. Oncol Res. 2009;18:17–23
  28. Abnet CC, Lai B, Qiao YL, Vogt S, Luo XM, Taylor PR, et al. Zinc concentration in esophageal biopsy specimens measured by X-ray fluorescence and esophageal cancer risk. J Natl Cancer Inst. 2005;97:301–6
  29. Lee DH, Anderson KE, Harnack LJ, Folsom AR, Jacobs DR. Heme, iron, zinc, alcohol consumption, and colon cancer: Iowa women’s health study. J Natl Cancer Inst. 2004;96:403–7
  30. Prasad AS, Beck FWJ, Doerr TD, Shamsa FH, Penny HS, Marks SC, et al. Nutritional and zinc status of head and neck cancer patients: An interpretive review. J Am College Nutr. 1998;17:409–18
  31. Abdulla M, Biorklund A, Mathur A, Wallenius K. Zinc and copper levels in whole blood and plasma from patients with squamous cell carcinomas of head and neck. J Surg Oncol. 1979;12:107–13
  32. Costello LC, Franklin RB, Feng P, Tan M, Bagasra O. Zinc and prostate cancer: a critical scientific, medical, and public interest issue (United States) Cancer Causes Control. 2005;16:901–15
  33. Daniel Plano, Deepkamal Karelia, Manoj Pandey, Shantu Amin, Arun K. Sharma. Development of novel selenium-NSAIDs as potential cancer therapeutics. [abstract]. In: Proceedings of the 104th Annual Meeting of the American Association for Cancer Research; 2013 Apr 6-10; Washington, DC. Philadelphia (PA): AACR; Cancer Res 2013;73(8 Suppl):Abstract nr 5553
  34. https://www.naturalnews.com/016446_selenium_nutrition.html. Dostopano 20.2.2018
  35. Clark LC, Combs GF, Turnbull BW, Slate EH, Chalker DK, Chow J, Davis LS, Glover RA, Graham GF, Gross EG, Krongrad A, Lesher JL, Park HK, Sanders BB, Smith CL, Taylor JR. Effects of Selenium Supplementation for Cancer Prevention in Patients With Carcinoma of the SkinA Randomized Controlled Trial. JAMA. 1996;276(24):1957–1963
  36. Klein EA, Thompson IM, Tangen CM, et al. Vitamin E and the Risk of Prostate Cancer: Updated Results of The Selenium and Vitamin E Cancer Prevention Trial (SELECT). JAMA. 2011;306(14):1549-1556
  37. Combs GF Jr, Clark LC, Turnbull BW. Reduction of cancer mortality and incidence by selenium supplementation. Med Klin (Munich). 1997 Sep 15;92 Suppl 3:42-5

Other literature:

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  • Pastorino U, Infante M, Maioli M, et al. Adjuvant treatment of early stage lung cancer with high-dose vitamins. J Clin Oncol 1993;11:1216-1222 
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