Femix nutrition supplement is intended for nutrition support while taking contraception pills.

Recommended daily dose: 1 capsule per day during a meal. Capsules contain a special, enteric packing (microcrystalline cellulose) that allow safe transition of ingredients through the stomach. Suitable for vegetarians. The product does not contain lactose, salt, gluten, artificial colors, flavors or preservatives. We recommend taking the supplement regularly when using contraceptive tablets.

Vitamin C
Vitamin B1 (Thiamine)
Vitamin B2 (Ribofavin)
Vitamin B6
Vitamin B9 (Folic Acid)
Vitamin B12
* Daily dose content by recommended daily amount

Oral hormonal contraception (hereinafter referred to as the birth control pill) is an important class of prescription pharmaceuticals used by an extremely large percentage of women who begin taking them already in Early adolescence.

Contraceptive pills work by disturbing the natural hormonal balance in our body. Synthetic forms of estrogen and progesterone prevent the normal course of ripening of the egg, prevent ovulation and alter the condition of our mucous membranes. Tablets with high levels of estrogen hormone can increase the risk of breast cancer, embolism and stroke. Consequently, newer versions of birth control pills contain lower amounts of hormones and therefore remain extremely popular, although they can still be harmful. But the side effects of contraceptive tablets are still talked about a lot, especially because of their metabolism in the liver. For this, extra amounts of vitamins B-complex, vitamin C, magnesium and zinc are consumed, due to which a long-term use of contraceptive tablets leads to a lack of these vitamins. As a result, users can start to gain weight, emotional oscillations emerge, they become depressed, chest becomes sensitive, and vaginal inflammation and heart disease can occur.

To date, a lot of research has been done with the desire to investigate the physiological changes in the taking of these tablets. These include changes in general health and nutritional needs. In terms of diet, more studies have been done to investigate whether women taking birth control pills require additional doses of certain vitamins and minerals. In particular, the World Health Organization (WHO) report is a study of major clinical significance (1) and should therefore receive greater attention.

The World Health Organization (WHO) notes that the use of birth control pills affects the absorption of important nutrients and, in particular, the decreased concentration of folic acid, vitamins B1, B2, B6, B12, vitamin C and minerals of magnesium, selenium and zinc (2, 3, 4).

V nadaljevanju vam bodo predstavljene tudi številne druge kakovostne raziskave, ki pričajo o nujnosti dodajanja določenih vitaminov in mineralov ob jemanju kontracepcijskih tablet.

  • Folic Acid

    Folate or Folic acid is a water-soluble vitamin B9, which is vitally important for many processes in the body. If you take contraception, it is proven that the contraceptives are involved in folate absorption and metabolism (5, 6, 7 8). It may thus be more obvious why there is a general problem with folic acid deficiency in the world, since contraceptive pills are widely used today. In one of a number of studies (9), it was found that the users of the contraceptive pill had a lower average serum folate, and a higher percentage of subnormal folate levels than a control group that did not take birth control pills. They also found that the average serum levels of folate in the contraceptive group decreased by an increased duration of use and that the folate level returned to the starting point values within 3 months after women stopped using birth control pills. The folic acid deficiency is expressed primarily in anemia, abnormal white blood cells counts, megaloblastic anemia, there may be atherosclerosis and thrombosis (10, 11, 12). Sufficient folic acid consumption is therefore important for a normal blood count. Folate is also closely related to iron and vitamin B12 (13), which are also important for good blood. Deficiency is often accompanied by depression, insomnia, forgetfulness, irritability and even dementia. In pregnant women, a lack of folic acid in the diet may lead to the birth of children with developmental disorders (14, 15, 16).

  • Vitamin B2 (Ribofavin)

    If a woman has a riboflavin deficiency even before starting to take birth control pills, the tablets will make the situation worse. The deficit of riboflavin is more common in women who do not consume enough milk, meat and dark green leafy vegetables. Women taking birth control pills should be careful about the appropriate intake of riboflavin (17, 18). Signs of deprivation can be seen as cracks in the corners of the lips, painful tongue, weight gain and dermatitis. The main effect of deficiency on metabolism is the reduced oxidation of fatty acids and the slowing down of metabolism (19). The lack of riboflavin is also associated with a lack of iron absorption, which can be due to changes in the small intestine fringes. If we lack a riboflavin, there is often also a lack of vitamin B6.

  • Vitamin B6

    Some studies have shown a disorder of vitamin B6 metabolism in women taking oral contraceptives (20, 21, 22, 23). These findings were based on blood tests and on the measurement of vitamin B6 levels in the urine. A recent large-scale US population study (24) found that vitamin B6 levels had significantly decreased in 75% of women who took birth control pills and did not use dietary supplements containing vitamin B6. The lack of vitamin B6 can cause anemia, brain irregularities, seizures, depression, confusion and dermatitis (24, 25, 26, 27, 28, 29, 30, 31).

  • Vitamin B12

    Vitamin B12 has many functions in our body. It helps build our DNA and helps in the operation of red blood cells. Because our body can not make it alone, we must bring it in with food. If we do not consume enough of it with food (organic vegetables, fruits, dairy products and meat), it is recommended to use a quality vitamin B12 supplement. In a study by Dr. Shojani and colleagues (32), the total vitamin B12 binding capacity was found to be significantly lower in women who use birth control pills than those who do not use them. Likewise, levels of transcobalamin I and glycoproteins that serve to protect vitamin B12 from degradation in acid in the stomach are significantly lower in users of contraceptive pills, which means lower absorption of vitamin B12 into the body. The lack of vitamin B12 occurs mainly when taking certain medicines such as proton pump inhibitors, statins, and hormonal contraception (32, 33, 34, 35), and also with a diet that completely excludes meat, dairy products and eggs (veganism). Deficiency can be very dangerous because the lack of vitamin B12 in infants leads to neurological, metabolic and hematologic defects and disorders. At a later stage, vitamin deficiency appears to be the largest in the form of disorders in the formation of bone marrow cells, leading to anemia with characteristic large red blood cells (megaloblastic anemia). Drastic deficiency can also cause degeneration of certain areas of the spinal cord (pharynular myelosis), which can cause permanent damage to the nervous system. A lack of vitamin B12 can also lead to poor memory, weight gain and dementia, and infertility and spontaneous abortion may occur.

  • Vitamin C

    Vitamin C can be measured in blood plasma and in cellular blood components containing platelets and white blood cells or leukocytes. They found that, in women who are taking oral contraceptives, levels of vitamin C in plasma and cellular components were reduced (35, 36, 37, 38, 39, 40). They have not yet fully explained the phenomenon, but they suspect that it’s due to changes in the copper metabolism. To determine the effect of taking birth control pills on the state of vitamin C in the body, scientists studied the amount of ascorbic acid in plasma leukocytes and platelets. It has been found that levels of vitamin C in platelets and leukocytes are significantly reduced by the use of birth control pills, in particular those containing estrogen, which have been found to increase the degree of vitamin C metabolism, thereby reducing its absorption in the body. In severe vitamin C deficiency, scurvy appears, characterized by painful, swollen and bleeding gums, poorly healing wounds, exhaustion. If the daily intake of vitamin C is low for a long time, it may lead to poor functioning of the immune system, poor wound healing, and a greater chance of developing heart disease and cancer.

  • Zinc

    The results of some studies have shown that the birth control pills cause the redistribution of zinc in the blood. It has been shown that women who take oral contraceptives have reduced zinc levels in blood plasma while the level of zinc in the blood cells has increased (41). Zinc deficiency in women using birth control pills has been studied since 1968, when women who used birth control pills had lower plasma zinc concentrations than women who did not take birth control pills (42). A number of studies carried out over the next decades have confirmed this finding (43, 44, 45, 46, 47). Zinc deficiency is associated with loss of appetite, dermatitis, and impaired immune function. In severe deficiency, reduced ability to taste, as well as hair loss, diarrhea and neuropsychiatric disorders may occur. Zinc stocks in the body are not very large, therefore constant input is required. The content of zinc in different organs is very different, about 70% is found in bones, skin and hair.

  • Selenium

    Selenium is a microelement that is present in the soil. We need it for the normal functioning of certain enzymes, it participates in the metabolism of thyroid hormones, and protects cells against oxidative stress. Several studies have shown that the birth control pills interfere with the absorption of selenium. Heese et al. (48) conducted a study involving 200 students, half of whom took low-dose oral contraceptives for at least 3 months. The differences in mean serum selenium concentrations among students taking contraceptive pills and those who were not, was statistically significant, since it was found that the selenium content in the serum of the students taking the contraceptive pills was up to 50% lower. Lack of selenium increases the likelihood of heart problems, kidney disease, cancer, atherosclerosis, and hair loss, changes in the skin and infertility (49, 50, 51, 52) may also occur.

  • Magnesium

    Magnesium in the body participates as a cofactor in many reactions, especially those that are important for the release of energy. It also works in the functioning of muscles and nerves – it helps to transmit stimuli to nerve synapses and muscle contraction. It plays an important role in the bone mineralization. Repeatedly, it has been demonstrated that, with the regular use of birth control pills, the serum magnesium concentration is reduced. Prophylactic treatment of postmenopausal osteoporosis with estrogen (one of the main active ingredients of the birth control pill) and calcium has also been shown to reduce the amount of serum magnesium (53). Consumption of birth control pills changes the ratio of calcium / magnesium, which can affect blood coagulability (too high proportion in favor of calcium). Therefore, reducing the level of magnesium in the serum is one of the reasons for an increased risk of thrombosis in the use of contraceptive pills. Signs of magnesium deficiency are confusion, changes in personality, depression, loss of appetite, muscle cramps, heart problems, high blood pressure and heart rhythm disorders.

For you, we have chosen the best research on which the above claims are based.
View Research


  1. World Health Organization: Vitamin and mineral requirements in Human nutrition. WHO Library; 1998
  2. Prasad AS, Lei KY, Moghissi KS, Stryker JC, Oberleas D. Effect of oral contraceptives on nutrients. III. Vitamins B6, B12, and folic acid. Am J Obstet Gynecol 1976; 125: 1063-1069
  3. Wilson SM, Bivins BN, Russell KA, Bailey LB. Oral contraceptive use: impact on folate, vitamin B(6), and vitamin B(1)(2) status. Nutr Rev 2011; 69: 572-583
  4. Wertalik LF, Metz EN, Lobuglio AF, Balcerzak SP. Decreased serum B 12 levels with oral contraceptive use. JAMA 1972; 221: 1371-1374
  5. Shojania AM, Hornady G, Barnes PH. Oral contraceptives and serum-folate level. Lancet 1968; 1: 1376-1377
  6. Trowbridge M, JR., Wadsworth RC, Moffitt E. Malabsorption associated with gluten enteropathy, do oral contraceptives interfere with folate metabolism? J Maine Med Assoc 1968; 59: 240-242
  7. Pritchard JA, Scott DE, Whalley PJ. Maternal folate deficiency and pregnancy wastage. IV. Effects of folic acid supplements, anticonvulsants, and oral contraceptives. Am J Obstet Gynecol 1971; 109: 341-346
  8. Castren OM, Rossi RR. Effect of oral contraceptives on serum folic acid content. J Obstet Gynaecol Br Commonw 1970; 77: 548-550
  9. Paton A. Oral contraceptives and folate deficiency. Lancet 1969; 1: 418
  10. Ryser JE, Farquet JJ, Petite J. Megaloblastic anemia due to folic acid deficiency in a young woman on oral contraceptives. Acta Haematol 1971; 45: 319-324
  11. Whitehead N, Reyner F, Lindenbaum J. Megaloblastic changes in the cervical epithelium. Association with oral contraceptive therapy and reversal with folic acid. JAMA 1973; 226: 1421-1424
  12. Wald NJ, Watt HC, Law MR, Weir DG, Mcpartlin J, Scott JM. Homocysteine and ischemic heart disease: results of a prospective study with implications regarding prevention. Arch Intern Med 1998; 158: 862-867
  13. Shojania AM. Oral contraceptives: effect of folate and vitamin B12 metabolism. Can Med Assoc J 1982; 126: 244-247
  14. Wald NJ, Bower C. Folic acid and the prevention of neural tube defects. Br Med J 1995; 310: 1019-1020
  15. Wald NJ, Gilbertson MP. Folic acid in prevention of neural tube defects. Lancet 1995; 345: 389
  16. Mosley BS, Cleves MA, Siega-riz AM, Shaw GM, Canfield MA, Waller DK, Werler MM, Hobbs CA. Neural tube defects and maternal folate intake among pregnancies conceived after folic acid fortification in the United States. Am J Epidemiol 2009; 169: 9-17
  17. Briggs M. Letter: Oral contraceptives and vitamin nutrition. Lancet 1974; 1: 1234-1235
  18. Newman LJ, Lopez R, Cole HS, Boria MC, Cooperman JM. Riboflavin deficiency in women taking oral contraceptive agents. Am J Clin Nutr 1978; 31: 247-249
  19. Brody T. Riboflavin. Nutritional Biochemistry. San Diego. Academic Press; 1999
  20. Leklem JE, Brown RR, Rose DP, Linkswiler HM. Vitamin B6 requirements of women using oral contraceptives. Am J Clin Nutr 1975; 28: 535-541
  21. Leklem JE. Vitamin B-6 requirement and oral contraceptive use--a concern? J Nutr 1986; 116: 475- 477
  22. Lumeng L, Cleary RE, Li TK. Effect of oral contraceptives on the plasma concentration of pyridoxal phosphate. Am J Clin Nutr 1974; 27: 326-333
  23. Lussana F, Zighetti ML, Bucciarelli P, Cugno M, Cattaneo M. Blood levels of homocysteine, folate, vitamin B6 and B12 in women using oral contraceptives compared to non-users. Thromb Res 2003; 112: 37-41
  24. Morris MS, Picciano MF, Jacques PF, Selhub J. Plasma pyridoxal 5’-phosphate in the US population: the National Health and Nutrition Examination Survey, 2003-2004. Am J Clin Nutr 2008; 87: 1446-1454
  25. Cattaneo M, Lombardi R, Lecchi A, Bucciarelli P, Mannucci PM. Low plasma levels of vitamin B(6) are independently associated with a heightened risk of deep-vein thrombosis. Circulation 2001; 104: 2442-2446
  26. Kirksey A, Morre DM, Wasynczuk AZ. Neuronal development in vitamin B6 deficiency. Ann N Y Acad Sci 1990; 585: 202-218
  27. Aycock JE, Kirksey A. Influence of different levels of dietary pyridoxine on certain parameters of developing and mature brains in rats. J Nutr 1976; 106: 680-688
  28. Robinson K, Mayer EL, Miller DP, Green R, Van Lente F, Gupta A, Kottke-Marchant K, Savon SR, Selhub J, Nissen SE, et al. Hyperhomocysteinemia and low pyridoxal phosphate. Common and independent reversible risk factors for coronary artery disease. Circulation 1995; 92: 2825-2830
  29. Wasynczuk A, Kirksey A, Morre DM. Effects of maternal vitamin B-6 deficiency on specific regions of developing rat brain: the extrapyramidal motor system. J Nutr 1983; 113: 746-754
  30. Wasynczuk A, Kirksey A, Morre DM. Effect of maternal vitamin B-6 deficiency on specific regions of developing rat brain: amino acid metabolism. J Nutr 1983; 113: 735-745
  31. Candito M, Rivet R, Herbeth B, Boisson C, Rudigoz RC, Luton D, JourneL H, Oury JF, Roux F, Saura R, VErnhet I, Gaucherand P, Muller F, Guidicelli B, Heckenroth H, Poulain P, Blayau M, Francannet C, Roszyk L, Brustie C, Staccini P, Gerard P, Fillionemery N, Gueant-Rodriguez RM, Van Obberghen E, Gueant JL. Nutritional and genetic determinants of vitamin B and homocysteine metabolisms in neural tube defects: a multicenter case-control study. Am J Med Genet A 2008; 146A: 1128-1133
  32. Shojania AM, Wylie B. The effect of oral contraceptives on vitamin B12 metabolism. Am J Obstet Gynecol 1979; 135: 129-134
  33. Riedel B, Bjorke Monsen AL, Ueland PM, Schneede J. Effects of oral contraceptives and hormone replacement therapy on markers of cobalamin status. Clin Chem 2005; 51: 778-781
  34. Sutterlin MW, Bussen SS, Rieger L, Dietl J, Steck T. Serum folate and Vitamin B12 levels in women using modern oral contraceptives (OC) containing 20 microg ethinyl estradiol. Eur J Obstet Gynecol Reprod Biol 2003; 107: 57-61
  35. Veninga KS. Effects of oral contraceptives on vitamins B6, B12, C, and folacin. J Nurse Midwifery 1984; 29: 386-390
  36. Palmery M, Saraceno A, Vaiarelli A, Carlomagno G. Oral contraceptives and changes in nutritional requirements. Eur Rev Med Pharmacol Sci. 2013 Jul;17(13):1804-13
  37. Webb JL. Nutritional effects of oral contraceptive use: a review. J Reprod Med 1980; 25: 150-156
  38. Schell DA, Bode AM. Measurement of ascorbic acid and dehydroascorbic acid in mammalian tissue utilizing HPLC and electrochemical detection. Biomed Chromatogr 1993; 7: 267-272
  39. Hudiburgh NK, Milner AN. Influence of oral contraceptives on ascorbic acid and triglyceride status. J Am Diet Assoc 1979; 75: 19-22
  40. Zal F, Mostafavi-Pour Z, Amini F, Heidari A. Effect of vitamin E and C supplements on lipid peroxidation and GSH-dependent antioxidant enzyme status in the blood of women consuming oral contraceptives. Contraception 2012; 86: 62-66
  41. Briggs MH, Briggs M, Austin J. Effects of steroid pharmaceuticals on plasma zinc. Nature 1971; 232: 480-481
  42. Halsted JA, Hackley BM, Smith JC, JR. Plasma-zinc and copper in pregnancy and after oral contraceptives
  43. Hambidge KM, Krebs NF. Zinc deficiency: a special challenge. J Nutr 2007; 137: 1101-1105
  44. Prema K, Ramalakshmi BA, Babu S. Serum copper and zinc in hormonal contraceptive users. Fertil Steril 1980; 33: 267-271
  45. King JC. Do women using oral contraceptive agents require extra zinc? J Nutr 1987; 117: 217- 219
  46. Fallah S, Sani FV, Firoozrai M. Effect of contraceptive pill on the selenium and zinc status of healthy subjects. Contraception 2009; 80: 40-43
  47. AkinloyE O, Adebayo TO, Oguntibeju OO, Oparinde DP, Ogunyemi EO. Effects of contraceptives on serum trace elements, calcium and phosphorus levels. West Indian Med J 2011; 60: 308-315
  48. Heese HD, Lawrence MA, Dempster WS, Pocock F. Reference concentrations of serum selenium and manganese in healthy nulliparas. S Afr Med J 1988; 73: 163-165
  49. Cann SA, Van Netten JP, Van Netten C. Hypothesis: iodine, selenium and the development of breast cancer. Cancer Causes Control 2000; 11: 121- 127
  50. Rejali L, Jaafar MH, Ismail NH. Serum selenium level and other risk factors for breast cancer among patients in a Malaysian hospital. Environ Health Prev Med 2007; 12: 105-110
  51. KnekT P, Marniemi J, Teppo L, Heliovaara M, Aromaa A. Is low selenium status a risk factor for lung cancer? Am J Epidemiol 1998; 148: 975-982
  52. Russo MW, Murray SC, Wurzelmann JI, Woosley JT, Sandler RS. Plasma selenium levels and the risk of colorectal adenomas. Nutr Cancer 1997; 28: 125- 129
  53. Seelig MS. Increased need for magnesium with the use of combined oestrogen and calcium for osteoporosis treatment. Magnes Res. 1990 Sep;3(3):197-215

Other literature:

  •  Mackey A, Davis S, Gregory J. Vitamin B6. X ed. Modern Nutrition in Health and Disease. M. Shils, Shike M, Ross A, Caballero B, Cousins R, Eds. Baltimore, MD. Lippincott Williams & Wilkins; 2005
  • Ronnenberg AG, Venners SA, Xu X, Chen C, Wang L, Guang W, Huang A, Wang X. Preconception Bvitamin and homocysteine status, conception, and early pregnancy loss. Am J Epidemiol 2007; 166: 304-312
  • Ronnenberg AG, Goldman MB, Chen D, Aitken IW, Willett WC, Selhub J, Xu X. Preconception folate and vitamin B(6) status and clinical spontaneous abortion in Chinese women. Obstet Gynecol 2002; 100: 107-113
  • Rose DP. The influence of oestrogens on tryptophan metabolism in man. Clin Sci 1966; 31: 265-272
  • Fischer H, Schwarzer C, Illek B. Vitamin C controls the cystic fibrosis transmembrane conductance regulator chloride channel. Proc Natl Acad Sci U S A 2004; 101: 3691-3696
  • WHO. Advances in Methods on Fertility Regulation. World Health Organization, 1975
  • Prasad AS, Oberleas D, Moghissi KS, Lei KY, Stryker JC. Effect of oral contraceptive agents on nutrients: I. Minerals. Am J Clin Nutr 1975; 28: 377-384
  • Nakashima AS, Dyck RH. Zinc and cortical plasticity. Brain Res Rev 2009; 59: 347-373
  • Wapnir RA. Protein Nutrition and Mineral Absorption. Boca Raton, Florida. CRC Press; 1990
  • Akinloye O, Adebayo TO, Oguntibeju OO, Oparinde DP, Ogunyemi EO. Effects of contraceptives on serum trace elements, calcium and phosphorus levels. West Indian Med J 2011; 60: 308-315
  • Nakashima AS, Dyck RH. Zinc and cortical plasticity. Brain Res Rev 2009; 59: 347-373