Femix nutrition supplement is intended for nutrition support while taking contraception pills.
Recommended daily dose: 1 capsule per day during a meal. Capsules contain a special, enteric packing (microcrystalline cellulose) that allow safe transition of ingredients through the stomach. Suitable for vegetarians. The product does not contain lactose, salt, gluten, artificial colors, flavors or preservatives. We recommend taking the supplement regularly when using contraceptive tablets.
Oral hormonal contraception (hereinafter referred to as the birth control pill) is an important class of prescription pharmaceuticals used by an extremely large percentage of women who begin taking them already in Early adolescence.
Contraceptive pills work by disturbing the natural hormonal balance in our body. Synthetic forms of estrogen and progesterone prevent the normal course of ripening of the egg, prevent ovulation and alter the condition of our mucous membranes. Tablets with high levels of estrogen hormone can increase the risk of breast cancer, embolism and stroke. Consequently, newer versions of birth control pills contain lower amounts of hormones and therefore remain extremely popular, although they can still be harmful. But the side effects of contraceptive tablets are still talked about a lot, especially because of their metabolism in the liver. For this, extra amounts of vitamins B-complex, vitamin C, magnesium and zinc are consumed, due to which a long-term use of contraceptive tablets leads to a lack of these vitamins. As a result, users can start to gain weight, emotional oscillations emerge, they become depressed, chest becomes sensitive, and vaginal inflammation and heart disease can occur.
To date, a lot of research has been done with the desire to investigate the physiological changes in the taking of these tablets. These include changes in general health and nutritional needs. In terms of diet, more studies have been done to investigate whether women taking birth control pills require additional doses of certain vitamins and minerals. In particular, the World Health Organization (WHO) report is a study of major clinical significance (1) and should therefore receive greater attention.
The World Health Organization (WHO) notes that the use of birth control pills affects the absorption of important nutrients and, in particular, the decreased concentration of folic acid, vitamins B1, B2, B6, B12, vitamin C and minerals of magnesium, selenium and zinc (2, 3, 4).
V nadaljevanju vam bodo predstavljene tudi številne druge kakovostne raziskave, ki pričajo o nujnosti dodajanja določenih vitaminov in mineralov ob jemanju kontracepcijskih tablet.
Folate or Folic acid is a water-soluble vitamin B9, which is vitally important for many processes in the body. If you take contraception, it is proven that the contraceptives are involved in folate absorption and metabolism (5, 6, 7 8). It may thus be more obvious why there is a general problem with folic acid deficiency in the world, since contraceptive pills are widely used today. In one of a number of studies (9), it was found that the users of the contraceptive pill had a lower average serum folate, and a higher percentage of subnormal folate levels than a control group that did not take birth control pills. They also found that the average serum levels of folate in the contraceptive group decreased by an increased duration of use and that the folate level returned to the starting point values within 3 months after women stopped using birth control pills. The folic acid deficiency is expressed primarily in anemia, abnormal white blood cells counts, megaloblastic anemia, there may be atherosclerosis and thrombosis (10, 11, 12). Sufficient folic acid consumption is therefore important for a normal blood count. Folate is also closely related to iron and vitamin B12 (13), which are also important for good blood. Deficiency is often accompanied by depression, insomnia, forgetfulness, irritability and even dementia. In pregnant women, a lack of folic acid in the diet may lead to the birth of children with developmental disorders (14, 15, 16).
Vitamin B2 (Ribofavin)
If a woman has a riboflavin deficiency even before starting to take birth control pills, the tablets will make the situation worse. The deficit of riboflavin is more common in women who do not consume enough milk, meat and dark green leafy vegetables. Women taking birth control pills should be careful about the appropriate intake of riboflavin (17, 18). Signs of deprivation can be seen as cracks in the corners of the lips, painful tongue, weight gain and dermatitis. The main effect of deficiency on metabolism is the reduced oxidation of fatty acids and the slowing down of metabolism (19). The lack of riboflavin is also associated with a lack of iron absorption, which can be due to changes in the small intestine fringes. If we lack a riboflavin, there is often also a lack of vitamin B6.
Some studies have shown a disorder of vitamin B6 metabolism in women taking oral contraceptives (20, 21, 22, 23). These findings were based on blood tests and on the measurement of vitamin B6 levels in the urine. A recent large-scale US population study (24) found that vitamin B6 levels had significantly decreased in 75% of women who took birth control pills and did not use dietary supplements containing vitamin B6. The lack of vitamin B6 can cause anemia, brain irregularities, seizures, depression, confusion and dermatitis (24, 25, 26, 27, 28, 29, 30, 31).
Vitamin B12 has many functions in our body. It helps build our DNA and helps in the operation of red blood cells. Because our body can not make it alone, we must bring it in with food. If we do not consume enough of it with food (organic vegetables, fruits, dairy products and meat), it is recommended to use a quality vitamin B12 supplement. In a study by Dr. Shojani and colleagues (32), the total vitamin B12 binding capacity was found to be significantly lower in women who use birth control pills than those who do not use them. Likewise, levels of transcobalamin I and glycoproteins that serve to protect vitamin B12 from degradation in acid in the stomach are significantly lower in users of contraceptive pills, which means lower absorption of vitamin B12 into the body. The lack of vitamin B12 occurs mainly when taking certain medicines such as proton pump inhibitors, statins, and hormonal contraception (32, 33, 34, 35), and also with a diet that completely excludes meat, dairy products and eggs (veganism). Deficiency can be very dangerous because the lack of vitamin B12 in infants leads to neurological, metabolic and hematologic defects and disorders. At a later stage, vitamin deficiency appears to be the largest in the form of disorders in the formation of bone marrow cells, leading to anemia with characteristic large red blood cells (megaloblastic anemia). Drastic deficiency can also cause degeneration of certain areas of the spinal cord (pharynular myelosis), which can cause permanent damage to the nervous system. A lack of vitamin B12 can also lead to poor memory, weight gain and dementia, and infertility and spontaneous abortion may occur.
Vitamin C can be measured in blood plasma and in cellular blood components containing platelets and white blood cells or leukocytes. They found that, in women who are taking oral contraceptives, levels of vitamin C in plasma and cellular components were reduced (35, 36, 37, 38, 39, 40). They have not yet fully explained the phenomenon, but they suspect that it’s due to changes in the copper metabolism. To determine the effect of taking birth control pills on the state of vitamin C in the body, scientists studied the amount of ascorbic acid in plasma leukocytes and platelets. It has been found that levels of vitamin C in platelets and leukocytes are significantly reduced by the use of birth control pills, in particular those containing estrogen, which have been found to increase the degree of vitamin C metabolism, thereby reducing its absorption in the body. In severe vitamin C deficiency, scurvy appears, characterized by painful, swollen and bleeding gums, poorly healing wounds, exhaustion. If the daily intake of vitamin C is low for a long time, it may lead to poor functioning of the immune system, poor wound healing, and a greater chance of developing heart disease and cancer.
The results of some studies have shown that the birth control pills cause the redistribution of zinc in the blood. It has been shown that women who take oral contraceptives have reduced zinc levels in blood plasma while the level of zinc in the blood cells has increased (41). Zinc deficiency in women using birth control pills has been studied since 1968, when women who used birth control pills had lower plasma zinc concentrations than women who did not take birth control pills (42). A number of studies carried out over the next decades have confirmed this finding (43, 44, 45, 46, 47). Zinc deficiency is associated with loss of appetite, dermatitis, and impaired immune function. In severe deficiency, reduced ability to taste, as well as hair loss, diarrhea and neuropsychiatric disorders may occur. Zinc stocks in the body are not very large, therefore constant input is required. The content of zinc in different organs is very different, about 70% is found in bones, skin and hair.
Selenium is a microelement that is present in the soil. We need it for the normal functioning of certain enzymes, it participates in the metabolism of thyroid hormones, and protects cells against oxidative stress. Several studies have shown that the birth control pills interfere with the absorption of selenium. Heese et al. (48) conducted a study involving 200 students, half of whom took low-dose oral contraceptives for at least 3 months. The differences in mean serum selenium concentrations among students taking contraceptive pills and those who were not, was statistically significant, since it was found that the selenium content in the serum of the students taking the contraceptive pills was up to 50% lower. Lack of selenium increases the likelihood of heart problems, kidney disease, cancer, atherosclerosis, and hair loss, changes in the skin and infertility (49, 50, 51, 52) may also occur.
Magnesium in the body participates as a cofactor in many reactions, especially those that are important for the release of energy. It also works in the functioning of muscles and nerves – it helps to transmit stimuli to nerve synapses and muscle contraction. It plays an important role in the bone mineralization. Repeatedly, it has been demonstrated that, with the regular use of birth control pills, the serum magnesium concentration is reduced. Prophylactic treatment of postmenopausal osteoporosis with estrogen (one of the main active ingredients of the birth control pill) and calcium has also been shown to reduce the amount of serum magnesium (53). Consumption of birth control pills changes the ratio of calcium / magnesium, which can affect blood coagulability (too high proportion in favor of calcium). Therefore, reducing the level of magnesium in the serum is one of the reasons for an increased risk of thrombosis in the use of contraceptive pills. Signs of magnesium deficiency are confusion, changes in personality, depression, loss of appetite, muscle cramps, heart problems, high blood pressure and heart rhythm disorders.
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